The town is served by Kasane International Airport (BBK). There are a few scheduled flights e.g. Air Botswana service to Gaborone and Maun and South African Airways (SAA) to Johannesburg, many not direct.
Travel distances in Africa tend to be great so before deciding to travel by road, be sure to check distances and enquire about road conditions. Ask your ABS travel consultant for advice.
There is a tarred road into Kasane from the east and south from Nata, which connects to tarred roads from Zimbabwe (notably Victoria Falls), and from Francistown, Maun, and Gaborone in Botswana.
Kasane has a bus stop, from where busses depart and arrive daily.
Many of the accommodations offer shuttles between Kasane and Livingstone/Vic Falls.
Nearby Kazungula has a ferry crossing to Zambia.